Biomedical - Systems Biology / Bioinformatics, Biomedical Engineering
Post-Doctoral Research Associate at NJIT
We are looking for a qualified, motivated and experienced Post-Doctoral Research Associate at The New Jersey Institute of Technology (NJIT) to conduct sponsored research on nanoparticles in biological systems. This project is a part of cooperative research effort between Army Research Laboratory (ARL), Aberdeen Proving Ground, MD and NJIT, Newark, NJ. The research is primarily focused on elucidating fundamentals of blast induced traumatic brain injury (TBI) including the Neuro-biochemistry, Nanotechnology and neurological outcome in small animal models. Under the direction of the Principal Investigators at ARL and NJIT, the candidate will engage in the synthesis, functionalization, characterization and delivery of nanoparticles to the brain on experimental rat models. Using cutting-edge technical tools, the candidate will identify active biological mechanisms and molecules through innovative particle delivery to target cells and proteins. The ideal candidates should demonstrate a good work ethic, work independently as well as in a team. This position will also require the ability to manage laboratory personnel, work with students at all levels, communicate with facilities management, collect, analyze, and present data in the group and in scientific forums, and publish in high quality journals. The work will be primarily performed at NJIT, Newark, NJ.
ESSENTIAL FUNCTIONS TO PERFORM:
Develop basic synthesis of functionalized nanoparticles or clusters that exhibit fluorescent properties even within cells.
Examine conjugation with antibodies and verify biocompatibility.
Explore imaging or other quantification methods
Identify methods for targeted delivery to cells, proteins in specific tissues in brain (crossing BBB)
Validate that the methods can be used for diagnostics and therapeutics
Perform other related duties as assigned.
Quantitative Western blots, ELISA, Q-RT-PCR
Brain tissue sectioning (vibratome/cryostat) and mounting
Confocal microscopy/digital pathology scanners
Animal surgery including stereotaxic, transcardial perfusion, intracerebral injections
Neural cell cultures, hippocampal slice cultures
Microsoft Office, statistical tools, graph pad software
Using data acquisition hardware
Candidates should hold a Ph.D. in Neuroscience, neurobiology, biochemisty, biology, biomedical/mechanical engineering or a related discipline or an M.D with research experience and interest in neuronal circuits. The candidate is expected to be proficient in spoken and written English. Prior experience in paired patch-clamp recordings, analysis of network oscillations (in vivo or in vitro) and/or live cell imaging would be valuable. Proficiency in PClamp, familiarity with NIS Elements or other image acquisition/analysis software and, LabView/Matlab, and an interest in computational modeling would be an asset.
Effective communication and writing skills.
Ability to be flexible and adapt to the changing needs of the team.
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